Brand name: Safr'Inside™
A patented, scientifically researched saffron extract that has been shown to cause a 60% decrease in overall stress levels, with effects being noticed in as little as 5 days. It has been shown to provide positive improvements in mood-related parameters, such as anxiety and depression, as well as promoting an increase in overall levels of happiness. Saffron can modulate the effects of mood-promoting neurotransmitters to reduce stress and anxiety and increase calmness and is therefore beneficial for sleep, improving insomnia severity as well as the ease of getting to sleep, sleep duration and overall sleep quality.
- Poor Sleep Quality
- Difficulty Falling Asleep
- Low Mood
Saffron is a well-known spice that is commonly utilised for its fragrance and richness in colour. It is the dried stigma of the flower that grows from the Crocus sativus plant and has been widely used in traditional medicine for its therapeutic properties and health benefits. It contains active compounds, such as safranal, which can have mood and sleep-promoting, as well as stress-relieving properties.
Safranal has been found to reduce levels of cortisol by up to 44%, which can assist in reducing feelings of stress, which otherwise impacts our mood levels and sleep quality. Studies found that the consumption of saffron reduced undesirable changes in heart rate which are usually caused by stress.
Saffron extract and its active compounds can also modulate the effects of serotonin, dopamine, norepinephrine, glutamate and GABA-A neurotransmitter which can have an impact on mood, stress, and calmness. Specifically, saffron has been found to contribute to improved concentration levels of serotonin, dopamine and other mood-related biomarkers in certain population groups. When used in conjunction with anxiety medication, saffron helps to enhance the anti-anxiety effects compared to placebo, therefore achieving results of reduced anxiety levels. Consuming saffron has also been found to reduce feelings of depression as well as improve happiness ratings.
This stress-relieving ingredient, therefore, has therapeutic benefits that can help those struggling with sleep and improve sleeping ability. It has shown to be helpful in improving insomnia severity, as well as improving the duration of non-restorative sleep (sleep which is usually characterised as not sufficiently refreshing or restorative). It is also effective in improving the ease of getting to sleep, sleep duration and overall sleep quality.
Two Islands Nightcap contains a specific saffron extract, Safr'Inside™️, in a researched dose, which has been shown to cause a 60% decrease in overall stress levels, with effects being noticed in as little as 5 days. Due to its extraction process Safr'Inside™️ in particular is the only encapsulated saffron extract on the market. This makes it 8 to 10 times richer in safranal, saffron’s main active compound, than other extracts, guaranteeing the effectiveness of the ingredient.
Safr'Inside™️ Saffron has been the subject of several proprietary studies including a clinical study assessing both chronic and acute efficacy (after only 30min), an in-vivo study showing the direct action of safranal on serotonin, and an open trial under medical supervision that demonstrated that 8 out of 10 consumers are satisfied by Safr’Inside™️ supplementation (and so much more).
Research and studies
We're led by an evidence-based approach, where each product – and every ingredient – has a purpose. As the science of nutrition evolves, we're constantly learning too.
Journal of Pharmacy and BioAllied Sciences
Saffron (Crocus sativus L.): as an antidepressant
Effects of saffron extract on sleep quality: a randomized double-blind controlled clinical trial
Journal of Clinical Sleep Medicine
Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial
Frontiers in Nutrition
Effects of saffron extract supplementation on mood, well-being, and response to a psychosocial stressor in healthy adults: a randomized, double-blind, parallel group, clinical trial
Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission
Safr’Inside™: the safranal-rich saffron extract that highlighted for the first time under medical supervision, a connection between its consumers’ feedbacks and proprietary clinical/ preclinical studies
Archives of Neuroscience
Effect of Saffron (Crocus sativus L.) as an Add-On Therapy to Sertraline in Mild to Moderate Generalized Anxiety Disorder: A Double Blind Randomized Controlled Trial
BMC Complementary medicine and therapies
The effect of Crocus sativus L. (saffron) herbal tea on happiness in postmenopausal women: a randomized controlled trial
Physiology and Behaviour